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Esashi Lab investigating genome stability control

The Esashi group aims to understand how proliferating human cells protect their genomic DNA against various environmental stresses e.g., radiation, genotoxic drugs as well as those arising from normal processes of cell growth e.g., replication, transcription. We are particularly interested in homologous recombination HR, which provides a powerful mechanism to repair broken DNA faithfully and

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Sir William Dunn School of Pathology

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DUSHEK LAB laboratory for molecular immunology

One of the major challenges in molecular immunology is no longer to identify new molecules but to understand the interaction networks that the identified molecules form. We are directly addressing this challenge by using quantitative molecular and cellular experiments combined with mechanistic and phenotypic models to understand the complex signaling networks underlying immune cell activation. We aim to exploit this knowledge for the benefit of human health.

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Esashi Lab investigating genome stability control

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The Esashi group aims to understand how proliferating human cells protect their genomic DNA against various environmental stresses e.g., radiation, genotoxic drugs as well as those arising from normal processes of cell growth e.g., replication, transcription. We are particularly interested in homologous recombination HR, which provides a powerful mechanism to repair broken DNA faithfully and

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The site had the following in the homepage, "Our previous studies revealed several unexpected regulatory mechanisms for HR, whereby the key HR proteins Rad51, BRCA2 and PALB2 are regulated spatio-temporally by central cell cycle kinases such as cyclin-dependent kinases CDKs and polo-like kinase 1 Plk1 in proliferating human cells." I noticed that the web site stated " The group continues to tackle challenging questions regarding the regulation of HR using a multidisciplinary approach, including protein biochemistry, molecular and cellular."

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