Overall, we focus on three main research questions. How do cell adhesion and polarity pathways regulate barrier formation, self-renewal and homeostasis in a stratified epithelium? How do cell adhesion and polarity pathways couple to signal transduction pathways to regulate stem cell behavior, barrier function and tissue homeostasis? How do age-associated alterations in molecular regulators of cell architecture alter progenitor cell behavior and result in impairment of the skin barrier? .

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