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KIF11 gene encodes a cytoskeletal protein that belongs to the kinesin-like protein family, BimC subfamily. Interacts with the thyroid hormone receptor in the presence of thyroid hormone. Plays a role in chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. Phosphorylation regulates its association with the spindle apparatus. IH of KIF11 in duodenum.
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The site had the following in the homepage, "The α-2-macroglobulin is a protease inhibitor." I noticed that the web site stated " It inhibits fibrynolysis by inactivating kallikrein and coagulation, by thrombin." They also stated " It is also involved in the transport of growth factors and cytokines small cell-signalling proteins secreted by the nervous and immune system such as platelet-derived growth factor, basic fibroblast growth factor, TGF-β, insulin or IL-1β. This protein is synthesized in the liver and found in the blood. Tissue line malignant melanoma."ANALYZE MORE BUSINESSES
The gene which codifies for this protein is part of a cluster of cytochrome P450 genes on chromosome 19. Mutations in this gene cause congenital adrenal hyperplasia. Structure of the protein from PDB in ModBase.
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